Collaborative development and spatial layout of industry is the core of regional development. Current domestic and international economic situation is undergoing profound changes，many enterprises are facing the risk of changes in The exchange rate of RMB，market competition is intensifying，the plight of the internal and external labor costs are high，and has formed a Forced mechanism，and discussing regional industrial Collaborative development and spatial layout is of great in this environment. There is a high degree of geo-spatial proximity on the stage of economic development in the Pearl River Delta region and has a strong similarity，at the same time. Most of the enterprises in the Pearl River Delta region are in a similar cultural background，and whether the convergence problem of the structure of industry in the Pearl River Delta region exists has a larger controversy. Pre-mainstream view is that the industrial structure is a high degree of convergence in the Pearl River Delta region，and this convergence means redundant construction in the region，and a serious waste of resources. Based on the estimates of Survey Report of the situation in the province of Guangdong Province in 2009，among the isomorphism coefficient of these three economic circles in the Pearl River Delta region，Shen-Guan-Hui is the highest，the average reached 0.88，Zhu-Zhong-Jiang is 0.72 Guang-Fo-Zhao is 0.49. In the pelorized of from 1998 to 2007，the isomorphism coefficient of Shen-Guan-Hui is only from 0.9 down to 0.88，Zhu-Zhong-Jiang dropped from 0.84 to 0.71，Guang-Fo-Zhao dropped from 0.63 to 0.49，so the report concluded：the industry isomorphic of these three major economic circles is a serious problem，especially in Shen-Guan-Hui. But recently，more views show that the similar industrial structure in the Pearl River Delta region is not serious problem，to the contrary，the industrial structure in the Pearl River Delta region is improving the degree of division of labor and coordination，and it has a great relationship between the PRD industrial division evolution and the local the conduct of the government466765. In view of the above analysis，the convergence of industrial structure in the Pearl River Delta region will be analyzed more on the base of the theory and we will begin to seek a theoretical basis，combining with empirical research，and exploring the strategy of coordinated development of regional industrial strategy and spatial layout.