This paper looks at the course of development of the Great Guangdong-Hong Kong-Macao tourism area over the past twenty years. The paper divides the tourism cooperation and development of Guangdong-Hong Kong-Macao into four stages：conceptual unification，mechanism establishment，system variance and pattern transition. Following analyzing the influence of three factors，institution，market and technology，this paper puts forward that it is prerequisite to choose a pattern of regional integration on the basis of “free trade area” for the Great Guangdong-Hong Kong-Macao tourism area. Then it expatiates that the basic innovational strategy of the developing mode in the Great Guangdong-Hong Kong-Macao tourism area is to set up a diversified harmonic mechanism，establish a coordinated developing strategy，construct a congregated industrial platform，activate interactive operational factors，carry out thematic integrated marketing communication and build up the Pan-Pearl Delta area as a whole.