Huaihe River is the first big river to be comprehensively and systematically governed in New China，and it is also the most difficult river to be governed in China and even in the world. In the new era，the new development concept provides a new guide for the joint harnessing of Huaihe River，the coordinated development of economy and society under the new development pattern of the 14^th Five-Year Plan provides a new guarantee for the joint harnessing of Huaihe River，and the implementation of Rural Revitalization Strategy provides a new path for the joint harnessing of Huaihe River. At present，there are still serious water pollution，overall shortage of water resources，destruction and encroachment of ecological environment in some regions in Huaihe River Basin. It is necessary for five provinces in Huaihe River Basin to realize joint governance by optimizing the institutional environment of cross-regional collaborative governance，carrying out cross-regional ecological environment legislation，establishing a list of cross-regional collaborative governance responsibilities，constructing a benefit adjustment mechanism of cross-regional collaborative governance，and constructing a cooperative governance pattern with multi-participation to help the calm of Huaihe River.