During the 13th Five-Year Plan period，the complicated changes of domestic and international environment were especially severely impacted by the COVID-19 epidemic. Driven by the “the belt and road initiative” initiative，coordinated regional development，winning the tough battle against poverty，building a well-off society in an all-round way，and supply-side structural reform，China’s cultural industry has generally shown steady and healthy development. The paths，modes，formats and characteristics of the development of inter-regional cultural industries are further highlighted，and the differences and imbalances in the development of inter-regional cultural industries are further highlighted. Besides，the pattern of competing development of regional differences in cultural industries is gradually formed. In the “14th Five-Year Plan” period，the development of regional cultural industry is faced with the challenges brought by the overall situation of the great rejuvenation strategy of the Chinese nation and the unprecedented changes in the world in a hundred years，as well as the persistent impact of the COVID-19 epidemic，which has brought greater uncertainty to the development of regional cultural industry. It is necessary to know and grasp the law of development in the new period，be good at nurturing opportunities in crisis and creating new situations in changing situations，and take supply-side structural reform and demand-side management as the main line. With cultural creativity，scientific and technological innovation，and industrial integration，we should promote new development momentum，constantly improve the modern cultural industry system and market system，and promote the distinctive and high-quality development of regional cultural industries. It will become the key power to realize the high-quality development of China’s economy under the double-cycle pattern，and lay a good foundation for building a strong socialist cultural country.